USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PSME1_HUMAN USC-OGP 2-DE database:  PSME1_HUMAN PSME1_HUMAN General information about the entry View entry in simple text format Entry name PSME1_HUMAN Primary accession number Q06323 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Proteasome activator complex subunit 1; AltName: Full=11S regulator complex subunit alpha; Short=REG-alpha; AltName: Full=Activator of multicatalytic protease subunit 1; AltName: Full=Interferon gamma up-regulated I-5111 protein; Short=IGUP I-5111; AltName: Full=Proteasome activator 28 subunit alpha; Short=PA28a; Short=PA28alpha;. Gene name Name=PSME1 Synonyms=IFI5111 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0492: pI=5.53; Mw=29365 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0773: pI=5.56; Mw=30293 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1265: pI=5.70; Mw=29445 Cross-references UniProtKB/Swiss-Prot Q06323; PSME1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PSME1_HUMAN Primary accession number Q06323 Secondary accession number(s) A6NJG9 H0YNE3 Q6IBM2 Q9UEF4 Sequence was last modified on  November 1, 1995 (version 1) Annotations were last modified on  March 15, 2017 (version 169) Name and origin of the protein Description RecName: Full=Proteasome activator complex subunit 1; AltName: Full=11S regulator complex subunit alpha; Short=REG-alpha; AltName: Full=Activator of multicatalytic protease subunit 1; AltName: Full=Interferon gamma up-regulated I-5111 protein; Short=IGUP I-5111; AltName: Full=Proteasome activator 28 subunit alpha; Short=PA28a; Short=PA28alpha; Gene name Name=PSME1 Synonyms=IFI5111 Encoded on Name=PSME1; Synonyms=IFI5111 Keywords 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Polymorphism; Proteasome; Reference proteome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL L07633; AAA16521.1; -; mRNA EMBL U10360; AAA53230.1; -; Genomic_DNA EMBL AF078829; AAF02217.1; -; Genomic_DNA EMBL BT019337; AAV38144.1; -; mRNA EMBL AK312211; BAG35144.1; -; mRNA EMBL CR456780; CAG33061.1; -; mRNA EMBL AL136295; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471078; EAW66105.1; -; Genomic_DNA EMBL BC000352; AAH00352.1; -; mRNA EMBL BC007503; AAH07503.1; -; mRNA EMBL AB007137; BAA28836.1; -; Genomic_DNA CCDS CCDS41930.1; -. [Q06323-2]; . CCDS CCDS61415.1; -. [Q06323-3]; . CCDS CCDS9612.1; -. [Q06323-1]; . PIR A54859; A54859; . RefSeq NP_001268457.1; NM_001281528.1. [Q06323-3]; . RefSeq NP_006254.1; NM_006263.3. [Q06323-1]; . UniGene Hs.75348; -; . PDB 1AVO; X-ray; 2.80 A; A/C/E/G/I/K/M=4-63 B/D/F/H/J/L/N=104-242 PDBsum; 1AVO; -; . ProteinModelPortal Q06323; -; . SMR Q06323; -; . BioGrid 111692; 77; . IntAct Q06323; 26; . MINT MINT-5002728; -; . STRING 9606.ENSP00000372155; -; . iPTMnet Q06323; -; . PhosphoSitePlus Q06323; -; . SwissPalm Q06323; -; . DMDM 1170519; -; . DOSAC-COBS-2DPAGE Q06323; -; . OGP Q06323; -; . SWISS-2DPAGE Q06323; -; . EPD Q06323; -; . PaxDb Q06323; -; . PeptideAtlas Q06323; -; . PRIDE Q06323; -; . TopDownProteomics Q06323-1; -. [Q06323-1]; . DNASU 5720; -; . Ensembl ENST00000206451; ENSP00000206451; ENSG00000092010. [Q06323-1]; . Ensembl ENST00000382708; ENSP00000372155; ENSG00000092010. [Q06323-2]; . Ensembl ENST00000561435; ENSP00000453976; ENSG00000092010. [Q06323-3]; . GeneID 5720; -; . KEGG hsa:5720; -; . UCSC uc001wmg.4; human. [Q06323-1]; . CTD 5720; -; . DisGeNET 5720; -; . GeneCards PSME1; -; . HGNC HGNC:9568; PSME1; . HPA HPA006632; -; . MIM 600654; gene; . neXtProt NX_Q06323; -; . OpenTargets ENSG00000092010; -; . PharmGKB PA33914; -; . eggNOG KOG4470; Eukaryota; . eggNOG ENOG410XQVX; LUCA; . GeneTree ENSGT00510000046374; -; . HOGENOM HOG000282822; -; . HOVERGEN HBG053745; -; . InParanoid Q06323; -; . KO K06696; -; . OMA TQISKYY; -; . OrthoDB EOG091G0GX7; -; . PhylomeDB Q06323; -; . TreeFam TF106236; -; . Reactome R-HSA-1169091; Activation of NF-kappaB in B cells; . Reactome R-HSA-1234176; Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha; . Reactome R-HSA-1236974; ER-Phagosome pathway; . Reactome R-HSA-1236978; Cross-presentation of soluble exogenous antigens (endosomes); . Reactome R-HSA-174084; Autodegradation of Cdh1 by Cdh1:APC/C; . Reactome R-HSA-174113; SCF-beta-TrCP mediated degradation of Emi1; . Reactome R-HSA-174154; APC/C:Cdc20 mediated degradation of Securin; . Reactome R-HSA-174178; APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1; . Reactome R-HSA-174184; Cdc20:Phospho-APC/C mediated degradation of Cyclin A; . Reactome R-HSA-180534; Vpu mediated degradation of CD4; . Reactome R-HSA-180585; Vif-mediated degradation of APOBEC3G; . Reactome R-HSA-187577; SCF(Skp2)-mediated degradation of p27/p21; . Reactome R-HSA-195253; Degradation of beta-catenin by the destruction complex; . Reactome R-HSA-202424; Downstream TCR signaling; . Reactome R-HSA-211733; Regulation of activated PAK-2p34 by proteasome mediated degradation; . Reactome R-HSA-2467813; Separation of Sister Chromatids; . Reactome R-HSA-2871837; FCERI mediated NF-kB activation; . Reactome R-HSA-349425; Autodegradation of the E3 ubiquitin ligase COP1; . Reactome R-HSA-350562; Regulation of ornithine decarboxylase (ODC); . Reactome R-HSA-382556; ABC-family proteins mediated transport; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-4608870; Asymmetric localization of PCP proteins; . Reactome R-HSA-4641257; Degradation of AXIN; . Reactome R-HSA-4641258; Degradation of DVL; . Reactome R-HSA-5358346; Hedgehog ligand biogenesis; . Reactome R-HSA-5362768; Hh mutants that don't undergo autocatalytic processing are degraded by ERAD; . Reactome R-HSA-5607761; Dectin-1 mediated noncanonical NF-kB signaling; . Reactome R-HSA-5607764; CLEC7A (Dectin-1) signaling; . Reactome R-HSA-5610780; Degradation of GLI1 by the proteasome; . Reactome R-HSA-5610783; Degradation of GLI2 by the proteasome; . Reactome R-HSA-5610785; GLI3 is processed to GLI3R by the proteasome; . Reactome R-HSA-5632684; Hedgehog 'on' state; . Reactome R-HSA-5658442; Regulation of RAS by GAPs; . Reactome R-HSA-5668541; TNFR2 non-canonical NF-kB pathway; . Reactome R-HSA-5676590; NIK-->noncanonical NF-kB signaling; . Reactome R-HSA-5678895; Defective CFTR causes cystic fibrosis; . Reactome R-HSA-5687128; MAPK6/MAPK4 signaling; . Reactome R-HSA-5689603; UCH proteinases; . Reactome R-HSA-5689880; Ub-specific processing proteases; . Reactome R-HSA-68827; CDT1 association with the CDC6:ORC:origin complex; . Reactome R-HSA-68949; Orc1 removal from chromatin; . Reactome R-HSA-69017; CDK-mediated phosphorylation and removal of Cdc6; . Reactome R-HSA-69229; Ubiquitin-dependent degradation of Cyclin D1; . Reactome R-HSA-69481; G2/M Checkpoints; . Reactome R-HSA-69601; Ubiquitin Mediated Degradation of Phosphorylated Cdc25A; . Reactome R-HSA-8852276; The role of GTSE1 in G2/M progression after G2 checkpoint; . Reactome R-HSA-8854050; FBXL7 down-regulates AURKA during mitotic entry and in early mitosis; . Reactome R-HSA-983168; Antigen processing: Ubiquitination & Proteasome degradation; . ChiTaRS PSME1; human; . EvolutionaryTrace Q06323; -; . GeneWiki PSME1; -; . GenomeRNAi 5720; -; . PRO PR:Q06323; -; . Proteomes UP000005640; Chromosome 14; . Bgee ENSG00000092010; -; . CleanEx HS_PSME1; -; . ExpressionAtlas Q06323; baseline and differential; . Genevisible Q06323; HS; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0005829; C:cytosol; TAS:Reactome; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; TAS:Reactome; . GO GO:0008537; C:proteasome activator complex; IEA:InterPro; . GO GO:0000502; C:proteasome complex; TAS:ProtInc; . GO GO:0061133; F:endopeptidase activator activity; IBA:GO_Central; . GO GO:0031145; P:anaphase-promoting complex-dependent catabolic process; TAS:Reactome; . GO GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I; TAP-dependent; TAS:Reactome GO GO:0038095; P:Fc-epsilon receptor signaling pathway; TAS:Reactome; . GO GO:0000165; P:MAPK cascade; TAS:Reactome; . GO GO:0090090; P:negative regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; TAS:Reactome; . GO GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome; . GO GO:0038061; P:NIK/NF-kappaB signaling; TAS:Reactome; . GO GO:0090263; P:positive regulation of canonical Wnt signaling pathway; TAS:Reactome; . GO GO:0010950; P:positive regulation of endopeptidase activity; IBA:GO_Central; . GO GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition; TAS:Reactome; . GO GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0016579; P:protein deubiquitination; TAS:Reactome; . GO GO:0000209; P:protein polyubiquitination; TAS:Reactome; . GO GO:0006521; P:regulation of cellular amino acid metabolic process; TAS:Reactome; . GO GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IBA:GO_Central; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0061136; P:regulation of proteasomal protein catabolic process; IBA:GO_Central; . GO GO:0061418; P:regulation of transcription from RNA polymerase II promoter in response to hypoxia; TAS:Reactome; . GO GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome; . GO GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome; . GO GO:0050852; P:T cell receptor signaling pathway; TAS:Reactome; . GO GO:0055085; P:transmembrane transport; TAS:Reactome; . GO GO:0033209; P:tumor necrosis factor-mediated signaling pathway; TAS:Reactome; . GO GO:0060071; P:Wnt signaling pathway; planar cell polarity pathway; TAS:Reactome Gene3D 1.20.120.180; -; 1; . Gene3D 1.20.5.120; -; 1; . InterPro IPR009077; Proteasome_activ_pa28; . InterPro IPR003186; Proteasome_activ_pa28_C; . InterPro IPR003185; Proteasome_activ_pa28_N; . PANTHER PTHR10660; PTHR10660; 1; . Pfam PF02251; PA28_alpha; 1; . Pfam PF02252; PA28_beta; 1; . SUPFAM SSF47216; SSF47216; 2; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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